Arachidonic acid in cell signaling

Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats.

Nicotine exerts its central effects by activating pre- and postsynaptic nicotinic acetylcholine receptors (nAChRs). Presynaptic nAChRs modulate the release of many neurotransmitters that bind to postsynaptic receptors. These may be coupled to the activation of cytosolic phospholipase A(2) (cPLA(2)), which hydrolyzes arachidonic acid (AA) from membrane phospholipids. We hypothesized that nicotin...

Orexin / Hypocretin Receptor Signaling via Arachidonic Acid and Endocannabinoid Release

Role of triglycerides in endothelial cell arachidonic acid metabolism.

Arachidonic acid was incorporated into triglycerides by cultured bovine endothelial cells in a time- and concentration-dependent manner. At 75 microM or higher, more arachidonic acid was incorporated into triglycerides than into phospholipids. The triglyceride content of the cells increased as much as 5.5-fold, cytoplasmic inclusions appeared, and arachidonic acid comprised 22% of the triglycer...

Increased cell membrane arachidonic acid in experimental colorectal tumours.

Tumour cell membrane fatty acid composition was investigated using an animal model of colorectal carcinogenesis. Eighty six male Wistar rats were fed experimental diets containing either 5% saturated fat or 20% saturated fat. Colorectal tumours were induced by intraperitoneal injection of azoxymethane, and control rats received saline. Animals were killed at intervals up to 26 weeks after the l...

Arachidonic Acid Metabolites in Inflammation